CONJUGUÉS D'ACIDE PHÉNYLÉTHANOÏQUE, D'ACIDE PHÉNYLPROPANOÏQUE ET D'ACIDE PHÉNYLPROPÉNOÏQUE ET PROMÉDICAMENTS D'HYDROCODONE, LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION

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专利权人:

INC.;KEMPHARM

发明人:

MICKLE, TRAVIS,GUENTHER, SVEN,MICKLE, CHRISTAL,CHI, GUOCHEN,KANSKI, JAROSLAW,MARTIN, ANDREA, K.,BERA, BINDU

申请号：

EP10794765

公开号：

EP2448408A4

申请日:

2010.07.01

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/