PROCÉDÉ POUR INDUIRE SÉLECTIVEMENT L'EXPRESSION D'UN GÈNE DANS UN TISSU ANAÉROBIE PAR UN PROMOTEUR DE TYPE ALCOOL DÉSHYDROGÉNASE ET SES UTILISATIONS

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专利权人:

NANJING UNIVERSITY

发明人:

HUA, ZICHUN,CHEN, JIANXIANG,WEI, DONGPING,ZHUANG, HONGQIN

申请号：

EP11863461

公开号：

EP2711420A4

申请日:

2011.05.13

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

A proteomic screening method for anaerobic-specific and expression-effective promoter, and a method of specially delivering and selectively stably expressing target gene in anaerobic tissue by an alcohol dehydrogenase promoter and uses thereof. The latter comprises an anaerobically-induced alcohol dehydrogenase promoter which is used as target gene promoter, anaerobic target bacteria and low copy number plasmid. Therefore, the target gene can be specially and highly expressed under hypoxia condition in vivo or in vitro. The selective gene expression which is driven by the alcohol dehydrogenase promoter in anaerobic tissue can be used as gene therapy method to treat anaerobic tissue disease including tumor, or to prepare anti-tumor drug.

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