PIERRE LOUIS BEAULIEU,JAMES GILLARD,YOULA S. TSANTRIZOS,MARTIN POIRIER,GEORGE KUKOLJ,GULREZ FAZAL,SYLVIE GOULET,MARC-ANDRE POUPART,JEAN RANCOURT,ERIC JOLICOEUR
申请号：
MYPI 20022780
公开号：
MY151080A
申请日:
2002.07.23
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
AN ISOMER, ENANTIOMER, DIASTEREOISOMER, OR TAUTOMER OF A COMPOUND, REPRESENTED BY FORMULA I: WHEREIN: A IS O, S, NR1, OR CR1, WHEREIN R1 IS DEFINED HEREIN； ---- REPRESENTS EITHER A SINGLE OR A DOUBLE BOND； R2 IS SELECTED FROM: H, HALOGEN, R21, OR21, SR21, C00R21, SO2N(R22)2, N(R22)2, CON(R22)2, NR22C(O)R22 OR NR22C(O)NR22 WHEREIN R21 AND EACH R22 IS DEFINED HEREIN； B IS NR3 OR CR3, WITH THE PROVISO THAT ONE OF A OR B IS EITHER CR1 OR CR3, WHEREIN R3 IS DEFINED HEREIN； K IS N OR CR4, WHEREIN R4 IS DEFINED HEREIN； L IS N OR CR5, WHEREIN R5 HAS THE SAME DEFINITION AS R4 DEFINED ABOVE； M IS N OR CR7, WHEREIN R7 HAS THE SAME DEFINITION AS R4 DEFINED ABOVE； Y1 IS O OR S； Z IS N(R6a)R6 OR OR6, WHEREIN R6a IS H OR ALKYL OR NR61R62 WHEREIN R61 AND R62 ARE DEFINED HEREIN； AND R6 IS H, ALKYL, CYCLOALKYL, ALKENYL, HET, ALKYL-ARYL, ALKYL-HET； OR R6 IS WHEREIN R7 AND R8 AND Q ARE AS DEFINED HEREIN； Y2 IS O OR S； R9 IS H, (C1-6 ALKYL), (C3-7)CYCLOALKYL OR (C1-6)ALKYL-(C3-7)CYCLOALKYL, ARYL, HET, (C1-6)ALKYL-ARYL OR (C1-6)ALKYL-HET, ALL OF WHICH OPTIONALLY SUBSTITUTED WITH R90； OR R9 IS COVALENTLY BONDED TO EITHER OF R7 OR R8 TO FORM A 5- OR 6-MEMBERED HETEROCYCLE； A SALT OR A DERIVATIVE THEREOF, AS AN INHIBITOR OF HCV NS5B POLYMERASE.
