LAIRSON, LUKE L.,CHIN, EMILY N.,CHATTERJEE, ARNAB,KUMAR, MANOJ,ALBERO, ANA MARIA GAMO,PETRASSI, MIKE,SCHULTZ, PETER,YU, CHENGUANG,TAMIYA, JUNKO,VERNIER, WILLIAM,GUPTA, ANIL,MODUKURI, RAMKUMAR
申请号：
CA3091670
公开号：
CA3091670A1
申请日:
2019.02.21
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention provides compounds having STimulator of INterferon Genes (STING) agonistic bioactivity that can be used in the treatment of tumors in patients afflicted therewith. The compounds are of formula (I): as defined herein. Compounds for practice of a method of the invention can be delivered via oral delivery for systemic exposure, as well as delivered intratumorally. Antitumor therapy using a compound of formula (I) can further comprise administration of an effective dose of an immune-checkpoint targeting drug.
