NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
发明人:
Takanori Yokota,Kotaro Yoshioka
申请号：
US16337808
公开号：
US20190240352A1
申请日:
2017.09.29
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided is a nucleic acid strand that can efficiently deliver an antisense oligonucleotide into the body, particularly a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein the first nucleic acid strand includes a base sequence that is capable of hybridizing with at least a portion of a target transcription product, and exerts an antisense effect on the target transcription product； the second nucleic acid strand includes a complementary region having a base sequence complementary to the first nucleic acid strand and at least one overhang region located on the 5′； and/or 3′； side of the complementary region； and the first nucleic acid strand is annealed to the complementary region in the second nucleic acid strand.
