An insert for a bed facilitates use of a mattress having one cross-sectional profile with a bed frame having a different cross-sectional profile. An insert includes a base extending between sidewalls which have various contoured surfaces. The contoured sidewall surfaces enable the insert to be disposed in a bed frame in association with a mattress. Inner surfaces of the sidewalls are configured to accommodate receipt of a mattress while outer surfaces of the sidewalls are configured for the insert to be disposed in a bed frame. The surface sidewalls may further be configured to provide the insert with a safety feature which prevents or reduces the likelihood of a user falling from the side of a mattress associated with the insert.