George M. Shaw,Hui Li,Beatrice H. Hahn,Barton F. Haynes
申请号：
US13821886
公开号：
US20140023683A1
申请日:
2011.09.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention provides methods for identifying HCV genomes and more specifically, methods for identifying nucleotide sequence of viral structural proteins at the time of HCV viral transmission. The method of the invention utilizes single genome amplification and sequencing of circulating virus as well as phylogenetic analysis of the resulting nucleotide sequence for identifying transmitted HCV genomes. Also provided are HCV genomes and corresponding nucleotide sequence for transmitted and circulating HCV virus. The invention further provides methods of administering a vaccine comprising one or more identified transmitted HCV sequences.
