PARK, HYEUNG GEUNKR,박형근,PARK, YO HANKR,박요한,LEE, HYO JONGKR,이효종
申请号：
KR1020130104922
公开号：
KR1014979620000B1
申请日:
2013.09.02
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
Disclosed are &alpha-alkyl-&alpha-carbonyl lactam derivatives having novel anticancer activity, a stereomer thereof, and a pharmaceutical composition containing the same. The composition including compounds of the present invention is effective in preventing and treating cancer. According to the present invention, the &alpha-alkyl-&alpha-carbonyl lactam derivatives have effects of preventing and treating cancer through a function of inhibiting growth of cancer cell, and especially show effect in cancer cells in which a p53 protein is inactivated unlike an existing MDM2 inhibitor, thereby being used for anticancer treatment.COPYRIGHT KIPO 2015본원은 신규한 항암활성을 갖는 알파-알킬-알파-카르보닐-락탐 유도체와 그 입체 이성질체 및 이를 함유하는 약학적 조성물을 개시하며, 본원에 따른 화합물을 포함하는 조성물은 암의 예방 및 치료에 유용하다.
