СМИТ Гейл (US),У Инюнь (US),МАССАРЕ Майкл (US),ЛЮ Е. (US)
申请号：
RU2014117068/10
公开号：
RU2014117068A
申请日:
2012.09.27
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method for preventing replication of the respiratory syncytial virus (RSV) in the lungs of the mammal, the mammal vklyuchayuschiyvvedenie fusion (F) protein of RSV, wherein the F-protein of RSV comprises (i) a deletion of one or more amino acids of a hybrid domain, a hybrid domain and corresponds to amino acids 137-154F-belka dikogo tipa of RSV (SEQ ID NO: 2) and (ii) an inactivated core furin cleavage site, the primary site furin cleavage corresponds to amino acids 131-136 of wild-type F-protein of RSV (SEQ ID NO: 2) and wherein the generated immune response that prevents RSV replication in legkih.2. The method of claim. 1, characterized in that the administration is intramuscular INTRODUCTION.3. A method according to Claim. 1, wherein the immune response comprises neutralizing antitela.4. A method according to claim 3, characterized in that the neutralizing antibodies bind to a polypeptide corresponding to amino acids 254-278 (SEQ ID NO: 35). Wild type of RSV.5 F-protein. A method according to claim. 3, characterized in that the neutralizing antibodies bind to at least two sites epitope F-protein of RSV, selected from the group consisting of site I, site II, site IV, site V, and site VI.6. The method of claim. 1, characterized in that administered from about 1 ug to about 30 ug of F-protein RSV.7. The method of claim. 1, characterized in that administered from about 1 ug to about 10 ug of F-protein RSV.8. The method of claim. 1, characterized in that the F-protein of RSV is administered without adyuvanta.9. The method of claim. 1, characterized in that the F-protein of RSV is administered adyuvantom.10. The method of claim. 1, characterized in that the immune response stimulated by the RSV-F-protein conjugate with reduced incidence of the pathological response induced by RSV in the lungs as compared with immune about1. Способ предупреждения репликации респираторно-синцитиального вируса (RSV) в легких млекопитающего, включающийвведение млекопитающему гибридног
