Jes Dietrich,Peter Andersen,Carina Vingsbo Lundberg,Truc Thi Kim Than Hoang
申请号：
US14569341
公开号：
US10519202B2
申请日:
2014.12.12
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention discloses a vaccine or immunogenic composition that can be administered to latently infected individuals to prevent reactivation of latent tuberculosis infection caused by species of the tuberculosis complex microorganisms (Mycobacterium tuberculosis, M. bovis, M. africanum), The invention is based on a number of M. tuberculosis derived proteins and protein fragments which are constitutively expressed in different stages of the infection. The invention is directed to the use of these polypeptides, immunologically active fragments thereof and the genes encoding them for immunological compositions such as vaccines.
