Described are methods for reducing the proliferation cancer cells by modulating the expression or activity of TOX such as by use of a TOX inhibitor. Inhibiting TOX expression with antisense nucleic acids is shown to reduce the proliferation of malignant T cells. Also described are methods for the treatment of cancer in a subject in need thereof comprising administering to the subject a TOX inhibitor. Optionally, the cancer is a T cell malignancy such as Cutaneous T cell Lymphoma (CTCL).
