The present invention discloses a kind of photochemical method for preparation of autologous plasma inactivated vaccine with what treatment AIDS, and characteristic includes the following steps in what; AIDS patient's autoblood is extracted, blood to be processed is formed; Blood to be processed is separated, blood plasma to be processed is obtained; Photosensitizer is added into blood plasma to be processed, forms blood plasma to be inactivated; Blood plasma to be inactivated is subjected to photoinactivation, obtains self Plasma Inactivation vaccine. The photochemical method for preparation of autologous plasma inactivated vaccine disclosed by the embodiments of the present invention with what treatment AIDS can prepare autologous plasma inactivated vaccine, vaccine is fed back to AIDS patient, and Hou can effectively enhance human immunity in vivo, reduce AIDS virus carrying capacity.本發明公開一種用於治療艾滋病的自體血漿滅活疫苗的光化學製備方法,其特徵在於,包括下列步驟;抽取艾滋病患者自體血液,形成待處理血液;分離待處理血液,獲得待處理血漿;向待處理血漿中加入光敏劑,形成待滅活血漿;將待滅活血漿進行光化學滅活,獲得自體血漿滅活疫苗。本發明實施例公開的用於治療艾滋病的自體血漿滅活疫苗的光化學製備方法能够製備出自體血漿滅活疫苗,將疫苗回輸到艾滋病患者本人體內後能够有效增强人體免疫力,降低艾滋病病毒載量。