PROBLEM TO BE SOLVED: To provide a compound as an effective ingredient, that is a pyrazolone compound, as an improved effective ingredient that responds to demands in pharmaceutical markets and that is effective for the treatment of diseases relating to ischemic stroke.SOLUTION: A drug for the treatment of cerebrovascular disorders associated with insufficient cerebral circulation such as ischemic stroke is provided, wherein the drug comprises a pharmaceutically effective amount of a pyrazolone compound expressed by structural formula (I) or a pharmaceutically acceptable salt thereof, or a pseudo-polymorphic form thereof, and wherein the drug is administered at a controlled dose in such a manner that the plasma concentration of unchanged form is kept constant for a predetermined period of time and that the compound exhibits a higher effect.COPYRIGHT: (C)2012,JPO&INPIT【課題】有効成分としての本発明の化合物、すなわちピラゾロン化合物を医薬品市場の要求に応え、脳梗塞に関連する疾患の治療に有用なように改善された有効成分として提供すること。【解決手段】薬学的に有効量の構造式(I):【化1】で表されるピラゾロン化合物、又はその化合物の薬学的に許容される塩、又は擬似結晶多型を含み、未変化体の血漿中濃度が所定の期間一定に維持され、かつ化合物がより高い効果を示すように制御された投与量で投与される、脳梗塞などの脳循環不全に関連する脳血管障害の治療薬。【選択図】なし
