Rebecca L. Casaubon,Radha Narayan,Christopher Oalmann,Chi B. Vu
申请号：
US15904993
公开号：
US20180186801A1
申请日:
2018.02.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
