In general, this disclosure describes techniques for monitoring ventricular capture of electrical stimulation based upon sensed ventricular pressures using an implantable medical device. One example method comprises obtaining a blood pressure signal for a first ventricle (e.g., right ventricle) of a patient, and determining whether stimulation captured a second, different ventricle (e.g., left ventricle) of the patient based upon the blood pressure signal for the first ventricle. Whether stimulation captured the second ventricle may be determined based on at least one value of a myocardial performance index that is determined based upon the blood pressure signal for the first ventricle. If a loss of capture is identified, the method may further comprise providing a warning signal and/or providing a therapy adjustment signal to adjust the electrical stimulation that is provided to the second ventricle.
