PROBLEM TO BE SOLVED: To provide compositions and food and drinks having an effect of enhancing the immune response to the antigen administered by an alternative pathway, such as a subcutaneous injection, by orally ingesting a lactic acid bacteria or a lactic acid bacterial culture or a processed product or a composition containing them.SOLUTION: A composition for oral ingestion which enhances the proliferation of a cytotoxic T-lymphocyte (CTL) specific to the antigen and production of an antibody specific to the antigen comprises a lactic-acid-bacteria strain, Lactococcus lactis subsp. lactis or a culture or processed product thereof, which enhances proliferation of a cytotoxic T-lymphocyte (CTL) and production of antibody, and the composition is used with an antigen which is a vaccine.SELECTED DRAWING: None【課題】乳酸菌又は乳酸菌の培養物若しくは処理物又はそれらを含有する組成物の経口摂取による、皮下注射などの別経路で投与した抗原に対する免疫反応を増強させる効果を有する、組成物及び飲食品の提供。【解決手段】細胞傷害性Ｔ細胞(CTL）の増殖及び抗体の産生を増強させる、Lactococcus lactis subsp.lactisである乳酸菌株又はその培養物若しくは処理物を含む、ワクチンである抗原と併用される、該抗原に特異的な細胞傷害性Ｔ細胞(CTL）の増殖及び該抗原に特異的な抗体の産生を増強するための、経口摂取用組成物。【選択図】なし
