연세대학교 산학협력단; YONSEI UNIVERSITY;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY;EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION;이화여자대학교 산학협력단;INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
KIM, Eosu,김어수,NAMKOONG, Kee,남궁기,JEONG, Ji Hyeon,정지현,JANG, Soo Ah,장수아,KWON, Young Joo,권영주,JUN, Kyu Yeon,전규연,JEON, Kyung Hwa,전경화
申请号：
KRKR2017/005061
公开号：
WO2018/212368A1
申请日:
2017.05.16
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a novel compound and a pharmaceutical composition, for preventing or treating degenerative neurological disorders, comprising the compound as an active ingredient. The novel compound, which is obtained by means of carrying out chemical modification in a mother structure showing excellent AMP-activated protein kinase (AMPK) activation and in silico binding capacity, enables effective prevention or treatment of degenerative neurological disorders by means of effectively inducing AMP-activated protein kinase (AMPK) enzyme activation.La présente invention concerne un nouveau composé et une composition pharmaceutique, destinée à prévenir ou à traiter des troubles neurologiques dégénératifs et qui comprend le composé en tant que principe actif. Le nouveau composé, qui est obtenu par la réalisation d'une modification chimique dans une structure mère présentant d'excellentes propriétés d'activation de la protéine kinase activée par l'AMP (AMPK) et une excellente capacité de liaison in silico, permet de prévenir ou de traiter efficacement des troubles neurologiques dégénératifs au moyen d'une induction efficace de l'activation enzymatique de la protéine kinase activée par l'AMP (AMPK).본 발명은 신규 화합물 및 상기 화합물을 유효성분으로 포함하는 퇴행성 신경질환의 예방 또는 치료용 약학 조성물에 관한 것으로, 에이엠피-활성 단백질 키나아제 활성 효능 및 인 실리코상 결합능이 좋은 모체 구조에서 화학적 변형(chemical modification)을 진행하여 얻어진 신규 화합물은 에이엠피-활성 단백질 키나아제(AMP-activated protein kinase；AMPK) 효소 활성화를 효과적으로 유도하여 퇴행성 신경질환을 효과적으로 예방 또는 치료할 수 있다.
