METHODS OF BLOCKING THE CXCR-4/SDF-1 SIGNALING PATHWAY WITH INHIBITORS OF BRUTONS TYROSINE KINASE

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专利权人:

发明人:

Raquel IZUMI,Francisco SALVA,Ahmed HAMDY

申请号：

US15303502

公开号：

US20170035756A1

申请日:

2015.04.10

申请国别(地区):

US

年份:

2017

代理人:

摘要：

In some embodiments, the present invention relates to novel small molecule inhibitors that block the CXCR4-SDF-1 signaling pathway by directly inhibiting members of the Tec family of kinases, namely Brutons tyrosine kinase (BTK), and their use in treating diseases in which pathogenesis is mediated by the CXCR4/SDF-1 signaling pathway.

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http://www.ckcest.cn/home/