Angiogenic protein kinase C peptide modulators

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专利权人:

カイ ファーマシューティカルズ インコーポレーティッド

发明人:

チェン レオン,ウォルター サラ,マクリーン デレク

申请号：

JP2008531446

公开号：

JP5269596B2

申请日:

2006.09.19

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The present invention provides peptides for inhibiting various protein kinase C isozymes. The peptide can be directed to any region of the protein kinase C isozyme, and in one embodiment, is directed to the V5 domain. The peptide can be conjugated to a carrier, in a releasable or non-releasable manner. The peptides can be used to inhibit angiogenesis and/or vascular permeability. The peptides can be used to treat subjects having, for example, cancer, diabetic blindness, macular degeneration, rheumatoid arthritis, or psoriasis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/