A method includes obtaining contrast-enhanced image data having a plurality of voxels, each voxel having an intensity value. The method further includes determining a vesselness value for each voxel. The method further includes determining a hypo-density value for each voxel. The method further includes weighting each of the intensity values by a corresponding vesselness value. The method further includes weighting each of the hypo- density values by the corresponding vesselness value. The method further includes combining the weighted intensity values and the weighted hypo-density values, thereby generating composite image data. The method further includes visually displaying the composite image data.