TARGETING HUMAN THYMIDYLATE KINASE INDUCES DNA REPAIR TOXICITY IN MALIGNANT TUMOR CELLS

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专利权人:

发明人:

Zee-Fen CHANG,Jim-Min FANG

申请号：

US15015878

公开号：

US20160151362A1

申请日:

2016.02.04

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention relates to novel TMPK inhibitor and their methods of use. In particular, it relates to novel TMPK inhibitor of Formula (I) and therapeutics that decrease the cellular dTTP level to suppress the growth and inhibit DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/