The detection sensitivity of single nucleotide acid polymorphic allele peoples DP2 genes is by pgd2 to hair growth inhibition

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专利权人:

ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア

发明人:

コトサレリス, ジョージ,ジェン, イン,シェ, ジェン-チー,オブライエン, ジョアン,コリンズ, デイビッド ダブリュー.

申请号：

JP2018504688

公开号：

JP2018530995A6

申请日:

2016.07.28

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

The reversed PGD2-mediated human hairs growth inhibition of DP-2 antagonists passes through the proliferation for reducing PGD2-triggered apoptosis and maintaining horn cell in a dose-dependent manner in vitro. Hair follicle shows that PGD2 influences the in-vitro method almost without neurological susceptibility from the baldness patient of about half. SNPs mankinds DP-2 genetic markers it is associated those by PGD2 hair growth inhibitions. These discoveries emphasize that role DP-2 regulating hair growths DP-2 is a kind of effective approach to this instruction, and the patient for preventing and/or treating androgen-dependent alopecia is sensitive to PGD2. It will benefit from treating moreover, SNPs identified here can be used to identify to suffer from.

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