The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid and a therapeutic agent (1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea), or pharmaceutically acceptable salts thereof, and a polymer. Other aspects include methods of making and using such nanoparticles.本揭示內容概言之係關於奈米顆粒，其包含實質上疏水性酸及治療劑(1-(4-{[4-(二甲基胺基)六氫吡啶-1-基]羰基}苯基)-3-[4-(4,6-二嗎啉-4-基-1,3,5-三嗪-2-基)苯基]脲)或其醫藥上可接受之鹽及聚合物。其他態樣包括製造及使用該等奈米顆粒之方法。
