The present invention relates to a method for treating insulin resistance, neuronal loss associated with stroke, ischemia, central nervous system trauma, a central nervous system disorder, a neurodegenerative disease, the adverse consequences of the over-stimulation of excitatory amino acids, a psychiatric disease, epilepsy or other convulsive disorder, chronic pain, CMV retinitis, urinary incontinence, or for inducing anesthesia； which comprises administering to an animal or human in need thereof an effective amount of a pharmaceutical formulation comprising an effective amount of a pyrone-indole derivative of formula (I): Ar&mdash；B&mdash；Ar&prime；&emsp；&emsp；(I) wherein Ar represents an indole nucleus ring system: Ar&prime； represents an alpha-, beta- or gamma-pyrone nucleus ring system: and each of B, R1-4, and R1-2&prime； are one of the groups as defined herein.本發明係關於新穎吡喃酮－吲哚衍生物、含有該等衍生物之醫藥調配物及該等化合物在製造用於治療或預防多種疾病之藥物中之用途。
