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DERIVADO DE 5H-PIRROLO[2,3-D]PIRIMIDIN-6(7H)-ONA NOVEDOSO.
专利权人:
TAIHO PHARMACEUTICAL CO.; LTD.
发明人:
Tetsuya SUGIMOTO,Toshihiro SAKAMOTO,Fuyuki YAMAMOTO,Yu KOBAYAKAWA,Naoki EGASHIRA,Koji ICHIKAWA,Takumitsu MACHIDA
申请号:
MX2018014022
公开号:
MX2018014022A
申请日:
2017.05.19
申请国别(地区):
MX
年份:
2019
代理人:
摘要:
The invention of the present application provides a compound represented by formula (I) or a salt thereof, which exhibits an inhibitory activity against at least one kinase selected from the group consisting of Akt kinase, Rsk kinase and S6K kinase and/or a cell proliferation inhibiting effect and is useful as a prophylactic and/or therapeutic agent for diseases associated with the above-mentioned kinases, particularly cancer. [In the formula, R1 represents a 4- to 6-membered monocyclic unsaturated heterocyclic group which has 1 to 3 hetero atoms independently selected from N, S and O and may have a substituent; R2 represents a hydrogen atom or the like; R3, R4 and R5 may be the same as or different from one another and independently represent a hydrogen atom or the like; R6 represents a hydrogen atom or the like; R7 and R8 may be the same as or different from each other and independently represent a hydrogen atom or the like; X1 and X2 may be the same as or different from each other and independently represent N or CR9; R9 represents a hydrogen atom or the like; and X3 represents N or CH when the broken line (---) represents a single bond, and represents C when the broken line represents a double bond; wherein at least one of X1 and X2 represents N.].La invención de la presente solicitud proporciona un compuesto representado por la fórmula (I) o una sal del mismo, que exhibe una actividad inhibidora contra al menos una cinasa seleccionada del grupo que consiste de la cinasa Akt, cinasa Rsk y cinasa S6K y/o un efecto inhibidor de la proliferación de células es útil como agente profiláctico y/o terapéutico para enfermedades asociadas con las cinasas mencionadas anteriormente, particularmente el cáncer. [En la fórmula, R1 representa un grupo heterocíclico insaturado monocíclico de 4 a 6 elementos que tiene 1 a 3 heteroátomos seleccionados independientemente de N, S y O y puede tener un sustituyente; R2 representa un átomo de hidrógeno o similar; R3, R4 y R5 pueden ser
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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