SALAS, JOE,萨拉斯 乔,薩拉斯 喬,PETERS, ROBERT T.,彼得斯 罗伯特,彼得斯 羅伯特,BITONTI, ALAN,毕托提 艾伦,畢托提 艾倫
申请号：
TW100124535
公开号：
TW201217526A
申请日:
2011.07.11
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
Chimeric clotting factors which localize the therapeutic to sites of coagulation (e.g., by being targeted to platelets or being activatable at sites of coagulation), have reduced clearance rates, have improved manufacturability, have reduced thrombogenicity, have enhanced activity, or have more than one of these characteristics are described as are methods for making chimeric clotting factors and methods for improving hemostasis using these clotting factors.嵌合凝血因數,其使定位在凝結部位(例如被靶向到血小板或在凝結部分被活化),其具有降低的清除率、提高的可製備性、降低的凝血活性、增強的活性或具有超過一個上述特徵,和製備這些嵌合凝血因數的方法,以及使用這些凝血因數改善止血的方法。
