AMY ARLENE WEAVER,DAVINDER GILL,DEBORAH A. YOUNG,HEATH M. GUAY,KARISSA K. ADKINS,LAIRD BLOOM,MARGOT O'TOOLE,MAYA ARAI,SADHANA JAIN,YULIA VUGMEYSTER
申请号：
BRPI0912998
公开号：
BRPI0912998A2
申请日:
2009.05.26
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.
