Guidewires are disclosed being configured to achieve variable rigidity to facilitate percutaneous exploration and the traversal of overlying elements such as catheters, for instance in performing the Seldinger technique. Embodiments of guidewires comprise sheaths and cores configured to be tightened together to achieve stiffness of the guidewire. Embodiments further include cores having an axial passage, along with one or more sections capable of independent activation to achieve variable rigidity. Embodiments also include guidewires comprising combinations of solid, wound metallic, polymeric coils, or woven meshes, with attached or detached polymer coatings. Cores may be configured to increase or decrease pressure, pass acoustic, ultrasonic or other mechanical energy, pass one or more metallic cores to interact with the distal mechanical elements, or as a channel to pass wires to activate the distal materials in the sections and distal tip.
