A prostate ablation system is described. The system comprises: a vapor generator; and a vapor delivery probe operatively coupled to the vapor generator and adapted to be inserted transurethrally into a prostate adjacent to a prostatic urethra of a patient, the vapor delivery probe adapted to deliver condensable vapor from the vapor generator into the prostate to deliver between 100 and 10,000 Joules to the prostate to ablate the prostate without ablating the prostatic urethra.