Provided are 3-cyano-1H-1,2,4-triazol-1-yl acetamide compounds represented by Formula (I), compositions, combinations, kits and uses of the compounds for treating HIV in a human, including using such compounds in combination with proteasome inhibitors. The compounds of the invention act by assisting activation of latent HIV-infected cells to enhance the activity of antiretroviral therapies and immune responses.