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Orally dispersible pharmaceutical composition and process for the preparation thereof
专利权人:
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
发明人:
Marchitto, Leonardo,Valenti, Mauro,Ragni, Lorella,Donati, Luca
申请号:
AU2005313588
公开号:
AU2005313588B2
申请日:
2005.11.25
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
A process for preparing an orally dispersible solid pharmaceutical form comprises the following steps: a) coating the active ingredient with at least one hydrophilic carboxylate polymer, b) granulating the coated active ingredient obtained in step (a) with at least one lipid compound having a melting point lower than that of the active ingredient, c) mixing the granulate obtained in step (b) with at least one hydrophilic natural polymer having high molecular weight, and d) mixing the granulate obtained in step (c) with ingredients suitable for obtaining an orally dispersible solid pharmaceutical form. An orally dispersible solid pharmaceutical form comprises an active ingredient coated with at least one hydrophilic carboxylate polymer and at least one lipid compound, in which the said coated active ingredient is embedded in a matrix comprising at least one hydrophilic natural polymer having high molecular weight.
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