PROBLEM TO BE SOLVED: To provide a novel production method of a skin tissue piece for implantation using compression processing, in which an optimal condition for the take of an epidermal cell or cultured skin, is determined, and the epidermal cell or cultured cell is implanted and taken to an inactivated skin by the compression processing, and to provide a skin tissue piece for implantation obtained by the method, and a novel application of the inactivated skin for taking the epidermal cell or cultured skin to a taken part, after implantation and taking to an object.SOLUTION: A skin tissue collected from a mammal is immersed in a solution, and a high hydrostatic pressure of 200-500 MPa is applied to the tissue for inactivating the tissue, thereby the inactivated skin tissue is produced. To the inactivated skin tissue, the epidermal cell or cultured skin is implanted and taken, before or after implantation to an individual to which a skin implantation therapy is desired.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】加圧処理を用いた移植用皮膚組織片の作製において、表皮細胞または培養表皮の生着のための最適な条件を決定し、以って加圧処理による不活化皮膚に表皮細胞または培養表皮を移植・生着させることを含む新規の移植用皮膚組織片の作製方法、それにより得られる移植用皮膚組織片、および対象への移植・生着後に生着部位に表皮細胞または培養表皮を生着させるための該不活化皮膚の新規用途、等を提供すること。【解決手段】哺乳動物より採取された皮膚組織を水溶液に浸し、該組織に200~500MPaの高静水圧を印加して該組織を不活化することにより作製された不活化された皮膚組織に、皮膚移植療法が所望される個体への移植前または移植後に表皮細胞または培養表皮を移植・生着させること。【選択図】なし
