DOTTI, GIANPIETRO,RAMOS, CARLOS A.,SAVOLDO, BARBARA
申请号：
CA2904369
公开号：
CA2904369A1
申请日:
2014.03.07
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Embodiments of the present disclosure concern therapeutic vectors and cells that target certain cancer cells but do not other cells having the same antigen. In specific embodiments, the methods and compositions of the disclosure concern cells having a CD138-specific chimeric antigen receptor whose expression is under the control of environment-specific regulation. In specific embodiments the environment is hypoxia. In some cases, the compositions comprise a suicide gene.
