The present invention relates to improved immunogenic compositions and vaccines, methods for making them and their use in medicine. In particular the invention relates to immunogenic compositions of unconjugated Streptococcus pneumoniae proteins selected from: pneumolysin and member(s) of the Polyhistidine Triad family (e.g. PhtD), which comprise adjuvants comprising QS21 and monophosphoryl lipid A (MPL), and are presented in the form of a liposome.本發明係關於經改良之免疫原性組合物及疫苗、其製備方法及其醫藥用途。特定而言，本發明係關於選自肺炎球菌溶血素及多組胺酸三合體家族成員(例如PhtD)之非偶聯(unconjugated)肺炎鏈球菌(Streptococcus pneumoniae)蛋白之免疫原性組合物，其包括含有QS21及單磷醯脂質A(MPL)之佐劑，且以脂質體形式呈現。
