KOCHHAR, CHARU,DEODHAR, UNMESH,KERUDI, ARAVIND,BABU, G V M
申请号：
NZ58631308
公开号：
NZ586313A
申请日:
2008.12.19
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed herein is a solid pharmaceutical composition suitable for oral administration comprising 3-(1.H.-indol-3-yl)-4-[2-(4-methyl-piperazin-1-yl)-quinazolin-4-yl]pyrrole-2,5-dione or a pharmaceutically acceptable salt thereof and at least one lubricant, wherein the composition comprises from 3 to 10% by weight of lubricant, wherein the lubricant is selected from the group consisting of Mg-stearate, Al-stearate, Ca-stearate, PEG 4000-8000, talc, sodium benzoate, glyceryl mono fatty acid, glyceryl monostearate, glyceryl dibehenate, glyceryl palmito-stearic ester, polyoxyethylene glycol, hydrogenated cotton seed oil, castor seed oil and vinylpyrrolidone-vinyl acetate copolymer, and the composition is in the form of a tablet, the total weight of the composition being the total tablet core weight.
