Colorado State University Research Foundation;State of Colorado acting by and on behalf of the Board of Trustees of the University of Northern Colorado
发明人:
Brian J. Geiss,Susan M. Keenan,Hillary Jo Beek
申请号：
US13907485
公开号：
US09206412B2
申请日:
2013.05.31
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides methods to inhibit the replication of a flavivirus, methods of inhibiting the guanosine triphosphate (GTP)-binding and guanylyltransferase activity of a flavivirus RNA capping enzyme, and methods of treating a subject infected with a flavivirus. The methods can include contacting a flavivirus with an effective amount of a thioxothiazolidine compound described herein, or a derivative thereof, such as a compound of Formula (I).
