The United States of America, as represented by the Secretary of Agriculture;LOUISIANA STATE UNIVERSITY
发明人:
Andrew Y. Li,Felicito Guerrero,Lane D. Foil,Adalberto A. Perez De Leon
申请号：
US15706895
公开号：
US10363292B2
申请日:
2017.09.18
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Compositions of either the Rm86Texas protein from a Texas outbreak strain of the southern cattle fever tick, Rhipicephalus microplus, or a nucleic acid construct incorporating a nucleic acid sequence encoding this Rm86Texas protein, are effective for eliciting a protective immune response in non-bovine animals. The Rm86Texas protein is immunogenic and can be administered as a protein vaccine, or in the alternative, the nucleic acid construct can be utilized as a DNA vaccine. Induction of the immune response significantly reduces or eliminates the infestation of treated, non-bovine animals with ticks. Moreover, as ticks are vectors of a variety of pathogens, the reduction in the incidence of tick infestation afforded by the vaccines may concurrently reduce the incidence of diseases caused by these pathogens in susceptible animals.
