Ali Can,Michael John Gerdes,Musodiq Olatayo Bello,Xiaodong Tao,Francis Edward Pavan-Woolfe,Roshni Bhagalia
申请号：
US12056078
公开号：
US08135187B2
申请日:
2008.03.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Techniques for removing image autoflourescence from fluorescently stained biological images are provided herein. The techniques utilize non-negative matrix factorization that may constrain mixing coefficients to be non-negative. The probability of convergence to local minima is reduced by using smoothness constraints. The non-negative matrix factorization algorithm provides the advantage of removing both dark current and autofluorescence.
