The present invention relates to modified coagulation Factor VII polypeptides exhibiting increased resistance to antithrombin inactivation and enhanced proteolytic activity. The present invention also relates to polynucleotide constructs encoding such polypeptides, vectors and host cells comprising and expressing such polynucleotides, pharmaceutical compositions, uses and methods of treatment.本發明係關於展現對於抗凝血酶不活化增加之抗性及增強之蛋白分解活性之經修飾凝血因子VII多肽。本發明亦關於編碼該等多肽之聚核苷酸構築體、包含及表現該等聚核苷酸之載體及宿主細胞、醫藥組成物、用途及治療方法。
