Comeau, Stephen R.,Nixon, Andrew,Kastrapeli, Niksa,Kenniston, Jon A.,Conley, Gregory P.,Mason, Shauna,Lindberg, Allison P.,Kopacz, Kristopher,Adelman, Burt
申请号：
AU2015373910
公开号：
AU2015373910A1
申请日:
2015.12.31
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Described herein are bispecific antibodies that bind to plasma kallikrein (pKal) and Factor XII and methods of producing and using such bi-specific antibodies for treating diseases or disorders associated with the contact system, e.g., hereditary angioedema or thrombosis. One aspect of the present disclosure is a bispecific antibody, comprising: a first polypeptide that comprises a light chain of a first antibody, the light chain comprising a light chain variable region (VL) and a light chain constant region (CL) (e.g., a kappa light chain or a lambda light chain)； and a second polypeptide that comprises a heavy chain of the first antibody, the heavy chain comprising a heavy chain variable region (VH) and a heavy chain constant region (CH).
