The present invention provides a novel TNF-α and IL-6 gene expression inhibitor resulting from exercise-induced skeletal muscle damage. (1) A TNF-α gene expression inhibitor comprising a black ginger extract as an active ingredient. Activator. (2) An IL-6 gene expression inhibitor comprising a black ginger extract as an active ingredient. (3) An agent for suppressing muscle inflammation caused by exercise-induced skeletal muscle damage, comprising the agent of (1) or (2) as an active ingredient. (4) A muscle pain improving agent comprising any one of the above (1) to (3) as an active ingredient. (5) A muscle fatigue improving agent comprising any one of the above (1) to (3) as an active ingredient. [Selection diagram] None【課題】運動誘発性骨格筋損傷に起因する新規なＴＮＦ－α及びＩＬ－６の遺伝子発現抑制剤を提供する。【解決手段】（１）黒ショウガ抽出物を有効成分とするＴＮＦ－α遺伝子発現抑制剤。活性化剤。（２）黒ショウガ抽出物を有効成分とするＩＬ－６遺伝子発現抑制剤。（３）上記（１）又は（２）の剤を有効成分とする運動誘発性骨格筋損傷に起因する筋肉炎症抑制剤。（４）上記（１）～（３）のいずれか1つの剤を有効成分とする筋肉痛改善剤。（５）上記（１）～（３）のいずれか1つの剤を有効成分とする筋肉疲労改善剤。【選択図】なし
