INVERSION DE LA LATENCE DE RÉTROVIRUS AVEC UNE PROTÉINE GALECTINE

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专利权人:

Inc.;University of Hawaii;Galpharma Co., Ltd.;Blood Systems;Blood Systems, Inc.

发明人:

PILLAI, Satish, K.,ABDEL-MOHSEN, Mohamed,CHAVEZ, Leonard,NDHLOVU, Lishomwa,TANDON, Ravi,NIKI, Toshiro,HIRASHIMA, Misuomi

申请号：

EP16765468

公开号：

EP3271020A4

申请日:

2016.03.10

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention relates to the seminal discovery of methods of using recombinant galectin proteins to reverse HIV latency. Specifically, the present invention relates to the use of recombinant galectin-9 (rGal-9) to reactivate latent HIV, wherein the HIV is hypermutated rendering the virus replication incompetent. Further, rGal-9 induces the expression of APOBEC3 cytidine deaminases and NFkB pathway components and decreases histone deacetylase (HDAC) expression.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/