A protective shield system protects a control interface of a wheelchair from environmental factors. The control interface includes a handle extending from a housing of the control interface to control motion of the wheelchair and one or more actuating mechanisms on the housing of the control interface to control one or more wheelchair functions. The protective shield system includes a flexible cover including at least one opening therein. The opening encompasses the handle when the cover is placed in operative connection with the control interface. The flexible cover further includes a releasable closure mechanism via which the at least one opening may be closed around a base of the handle. At least a portion of the flexible cover which is placed over the one or more actuating mechanisms is translucent. The one or more actuating mechanisms are actuatable by a user of the wheelchair by contact by the user with an outer surface of the portion of the flexible cover which is placed over the one or more actuating mechanisms.
