VAN DEN BRINK, EDWARD NORBERT,DE KRUIF, CORNELIS ADRIAAN,THROSBY, MARK
申请号：
CA2663388
公开号：
CA2663388C
申请日:
2007.09.06
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the ant ibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross- subt ype protection in vivo, such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.
