Monitoring and inhibiting human immunodeficiency virus infection by modulating HMGB1 dependent triggering of HIV-1 replication and persistence

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专利权人:

发明人:

Marie-Lise Gougeon,Hela Saidi,Marie-Therese Melki,Beatrice Poirier-Beaudoin,Valerie Seffer

申请号：

US14073112

公开号：

US09164103B2

申请日:

2013.11.06

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/