1.4 - diazepanos Derivatives of pyrazolo [4,3-d] pyrimidine, Preparation Method, Pharmaceutical compositions containing them and Use thereof for the treatment of erectile dysfunction
GARCIA ARMENTA MARIA ELENA,ALVAREZ OCHOA VICTOR GUILLERMO,OSNAYA MORALES ROBERTO CARLOS,ZARATE BARAJAS ERIKA ALEJANDRA
申请号：
ARP110101965
公开号：
AR081650A1
申请日:
2011.06.07
申请国别(地区):
AR
年份:
2012
代理人:
摘要：
Claim 1: A compound of the general formula (1) wherein A has a carbon or nitrogen atom； R1 represents a proton, C1-6 straight or branched chain alkyl, C3-6 cycloalkyl, a COR6 group, a C1-8 carboxylic acid derivative, a mono-ring heterocyclic or fused ring system of three to six members each ring, of one to five heteroatoms； R2 represents a proton, C1-6 straight or branched chain alkyl, a C3-6 cycloalkyl or a C1-3 alkoxy； R3 represents a proton, a C1-6 straight or branched chain alkyl, a hydroxyl, optionally substituted C1-3 alkoxy, a halogen,Single ring heterocyclic or fusion ring system, 3-6 for each member, consisting of 1-5 heteroatoms； R4 represents proton, c1-8 linear chain tar or branch, at the end of the chain there may or may not be a hydroxyl group, C3-6 cyclododecane, where there may or may not be a hydroxyl group, a group Derived from cor7, a group of co2r8 derivatives, a c1-8 carboxyl acid derivative, which can be directly linked to the nitrogen of 1.4-diazepano, or has one, two or three methylene units, or an ammonia protection group before the substance； R5 represents a proton, C1-6 linear chain tar or branch, or a functional group used as a hydroxyl group,e. R6 represents a proton or C1-6 linear or separable chain tar； R7 represents a proton, C1-6 linear or separable chain tar, C3-6 cyclopropene, which may be a saturated cycle or an aromatic cycle, or may contain a heterogeneous cycle, which may be local, full or unsaturated； R8 represents protons, C1-6 linear or separable chain tar, C3-6 cyclododecane, in which the ring may be saturated or aromatic, or may contain groups such as benzene or methylene fluoride； and their salts, compound N-oxides, corresponding isomers, symmetric isomers, isotopes, and ceramic forms.Reivindicación 1: Un compuesto de la fórmula general (1) en donde A presenta un átomo de carbono o nitrógeno； R1 representa un protón, alquilo C1-6 de cadena lineal o ramificada, cicloalquilo C3-6, un grupo COR6, un derivado de ácido carboxí
