PURPOSE: An MIF(macrophage migration inhibitory factor) secretion inhibitor is provided to be administered as an external skin formulation and to suppress MIF function. CONSTITUTION: An MIF secretion inhibitor contains Calendula officinalis extract. An external use skin formulation contains the inhibitor. An agent for treating inflammatory diseases contains the inhibitor. The extract is prepared from Calendula officinalis whole plant, flowers, leaves, stems, leaves, and roots using water, ethanol, ether, acetone, 1,3-butylene glycol, 1,2-pentandiol, propylene glycol, ethyl acetate. The extract also contains a fraction prepared by purifying the extract by various chromatographies. [Reference numerals] (AA) MIF secretion rate(%)； (BB) Vehicle； (CC) 100% BG extract of Calendula officinalis본 발명은 MIF 분비 억제제를 제공하는 것을 과제로 한다.상기 과제를 해결하기 위해, 본 발명의 MIF 분비 억제제는 당금잔화 또는 그의 추출물을 포함하는 대식세포 유주 저지인자 분비 억제제인 것을 특징으로 한다.
