DERIVES DE 2,4,6,7-TETRAHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-5-ONE ET COMPOSES APPARENTES EN TANT QUE MODULATEURS DU RECEPTEUR C5A POUR LE TRAITEMENT DE LA VASCULARITE ET DE MALADIES INFLAMMATOIRES
FROIDEVAUX, SYLVIE,HUBLER, FRANCIS,MURPHY, MARK,RENNEBERG, DORTE,STAMM, SIMON
申请号：
CA3086310
公开号：
CA3086310A1
申请日:
2019.01.09
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention relates to derivatives of formula (I) wherein Ring A, X, Y, Z, RA, R1, R2, R3 and R4 are The present invention discloses derivatives of formula (I), wherein Ring A, X, Y, Z, RA, R1, R2, R3 and R4 are as described in the description, and in particular e.g. 2,4,6,7-tetrahydro-pyrazolo[4,3- d]pyrimidin-5-one derivatives and related compounds, their preparation, pharmaceutically acceptable salts thereof, their use as pharmaceuticals, pharmaceutical compositions containing one or more compounds of formula (I), and especially their use as C5a receptor modulators for treating e.g. vasculitis and inflammatory diseases.
