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(1R, 2R) -3- (3- Dimethylamino-1-ethyl-2-methyl - propyl) abuse prevention oral dosage form containing phenol
专利权人:
グリューネンタール・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング
发明人:
バルトロメウス,ヨハネス,クーゲルマン,ハインリヒ,アルケナウ‐マリック,エリザベス,バルトロメウス,ヨハネス,クーゲルマン,ハインリヒ,アルケナウ‐マリック,エリザベス
申请号:
JP2007518529
公开号:
JP5700904B2
申请日:
2005.06.29
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled release of (1R, 2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol for a once daily administering. The invention is characterized in that the oral dosage form comprises the active ingredient and/or one or more pharmaceutically acceptable compounds (A) thereof, at least one synthetic and/or natural polymer (C), retarding adjuvants, optionally comprises additional physiologically compatible adjuvants (B), and optionally comprises a wax (D). The oral dosage form has a breaking resistance of at least 500 N, preferably at least 750 N. The dosage form contains at least one of the following abuse-preventing constituents (a)-(f); (a) at least one substance that irritates the nasal and/or pharyngeal cavity; (b) at least one viscosity-increasing agent; (c) at least one antagonist for the active ingredient having an abuse potential; (d) at least one emetic; (e) at least one colorant serving as an aversive agent, and; (f) at least one bitter substance.
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中国工程科技知识中心
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http://www.ckcest.cn/home/
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