The present invention relates to a magnetic resonance imaging (MRI) system (200) for acquiring magnetic resonance data from a target volume in a subject (218). The MRI system (200) includes a memory (236) for storing machine-executable instructions and a processor (230) for controlling the MRI system (200), and executes the machine-executable instructions. Includes a first MRI sequence including, in the processor (230), a first selective RF pulse (413) followed by a first excitation RF pulse (415) for controlling the MRI system (200). (401) is adapted to selectively excite and saturate exchangeable amide protons in the target volume and excite bulk water protons in the target volume within a first frequency range. Irradiating the target volume with the first excitation RF pulse (415) having the first excitation RF pulse 415), a second selective RF pulse (423) for acquiring first magnetic resonance imaging data from the target volume and controlling the MRI system (200), followed by a second excitation. A second MRI sequence (403) including an RF pulse (425) is used to selectively excite and saturate the exchangeable amide protons in the target volume within a second frequency range, and The target volume is illuminated by the second excitation RF pulse (425) adapted to excite water protons, and in response to the second excitation RF pulse (425), a second magnetic field is emitted from the target volume. Resonance imaging data is acquired, and the first MRI sequence (401) includes the second MR Including a gradient (417) having a first gradient polarity obtained by inverting the second gradient polarity sequence (403) (427).本発明は、被験体（２１８）内のターゲットボリュームから磁気共鳴データを取得するための磁気共鳴イメージング（ＭＲＩ）システム（２００）に関する。当該ＭＲＩシステム（２００）は、機械実行可能命令を記憶するためのメモリ（２３６）と、当該ＭＲＩシステム（２００）を制御するためのプロセッサ（２３０）と、を備え、前記機械実行可能命令の実行は、前記プロセッサ（２３０）に、当該ＭＲＩシステム（２００）を制御するための第１の選択的ＲＦパルス（４１３）及びその後に続く第１の励起ＲＦパルス（４１５）を含む第１のＭＲＩシーケンス（４０１）を使用して、第１の周波数範囲内で、前記ターゲットボリューム内の交換可能なアミドプロトンを選択的に励起及び飽和させ、前記ターゲットボリューム内のバルク水プロトンを励起させるよう適
